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Study on the Absolute Configurations of 3‐Alkylphthalides using TDDFT Calculations of Chiroptical Properties
Author(s) -
Li Li,
Si YiKang
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22086
Subject(s) - chemistry , circular dichroism , time dependent density functional theory , chirality (physics) , absolute configuration , alkyl , ab initio , computational chemistry , cotton effect , density functional theory , vibrational circular dichroism , optical rotatory dispersion , solvent effects , solvent , stereochemistry , organic chemistry , quantum mechanics , chiral symmetry , physics , nambu–jona lasinio model , quark
Absolute configurations (ACs) of 3‐alkylphthalides including natural products (−)‐3‐ n ‐butylphthalide ( (S)‐1 ) and fuscinarin have been studied using chiroptical properties and quantum chemical calculation. Electronic circular dichroism and optical rotatory dispersion spectra of (S)‐1 predicted adopting time‐dependent density functional theory and hybrid functionals coincide very well with the experimental and literature data of (S)‐1 , leading unambiguously to AC assignment as S for levorotatory isomer. The relationship between structures and chiroptical properties of 3‐alkylphthalides were also studied using theoretical calculation. It is found that when the alkyl group is adjacent to the single chiral center in the molecule, both the length of the alkyl side chain and the polarity of solvent may exert significant effect on electronic circular dichroism spectra. On the basis of these observations, it is recommended that the long‐chain alkyl group may be replaced by at least propyl instead of methyl group in such compounds. The present work shows that combination of chiroptical properties and ab initio calculations can provide a feasible and reliable way to the AC establishment of novel 3‐alkylphthalide derivatives with a high degree of confidence. Chirality 24:987‐993, 2012 . © 2012 Wiley Periodicals, Inc.