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Enantioseparation of Racemic Mixtures Based on Solvent Sublation
Author(s) -
Jiao Feipeng,
Yang Weijie,
Wang Fen,
Tian Lingxing,
Li Lin,
Chen Xiaoqing,
Mu Kelang
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22067
Subject(s) - chemistry , enantiomer , phosphoric acid , solvent , chirality (physics) , tartaric acid , chromatography , aqueous solution , racemic mixture , enantiomeric excess , organic chemistry , enantioselective synthesis , catalysis , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , citric acid , quark
ABSTRACT A method of solvent sublation was developed for the enantioseparation of racemic ofloxacin ( rac Oflx) and racemic tryptophan ( rac Trp). In this method, dibenzoyl‐ L ‐tartaric acid ( L ‐DBTA) and di‐(2‐ethylhexyl) phosphoric acid (D2EHPA) and sodium lauryl sulfate (SDS) were used as chiral coextractants and foamer, respectively. Several important parameters influencing the separation performances, such as pH in aqueous phase, concentrations of rac mixtures, L ‐DBTA, D2EHPA, and SDS, were investigated. Under the optimal operation conditions, the enantiomeric excess and enantioselectivity were 60.08% and 5.58 for Oflx and 65.09% and 6.31 for Trp, respectively. The yields of D ‐enantiomer and L ‐enantiomer were 34.23% and 8.54% for Oflx and 18.59% and 3.93% for Trp, respectively. The results suggest that the enantioselectivities have been enhanced compared with the traditional chiral extraction. This technique is an efficient chiral separation method, with many advantages such as low expenditures of organic solvent, low consumption of chiral extractant, and easy realization of multistage operation. Chirality 24:661‐667, 2012 . © 2012 Wiley Periodicals, Inc.