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Chitosan‐Based Heterogeneous Catalysts for Enantioselective Michael Reaction
Author(s) -
Qin Yanyan,
Zhao Wenshan,
Yang Lili,
Zhang Xuan,
Cui Yuanchen
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22058
Subject(s) - enantioselective synthesis , stereocenter , chemistry , michael reaction , cinchona , stereoselectivity , chitosan , catalysis , enantiomer , organocatalysis , chirality (physics) , organic chemistry , cinchona alkaloids , combinatorial chemistry , enantiomeric excess , chiral symmetry breaking , physics , nambu–jona lasinio model , quantum mechanics , quark
Novel chitosan‐supported cinchona alkaloids have been developed as heterogeneous catalysts for enantioselective Michael reaction . As‐synthesized products as organocatalysts for asymmetric Michael reaction have a high efficiency, providing highly functionalized products (containing adjacent quaternary and tertiary stereocenters) with good stereoselectivity (up to 93% enantiomeric excess) in high yields and recyclability (up to five runs). Chirality 24:640–645, 2012 . © 2012 Wiley Periodicals, Inc.