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Supramolecular arrangement of guanosine/5′‐guanosine monophosphate binary mixtures studied by methods of circular dichroism
Author(s) -
Novotná Jana,
Goncharova Iryna,
Urbanová Marie
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22045
Subject(s) - chemistry , circular dichroism , supramolecular chemistry , guanosine , chirality (physics) , supramolecular chirality , molecule , crystallography , stereochemistry , organic chemistry , biochemistry , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
Self‐assembly of molecules is one of the fundamental processes in biology and in supramolecular chemistry. Guanosine (Guo) and its derivatives are among the widely studied molecules because of self‐assembly abilities. Their tetrameric associates are the nature of telomeric DNA, and furthermore they are fundamental building blocks of supramolecular reversible gels, which may arise in certain physical and chemical conditions. Although poorly soluble in water, Guo forms interesting structures with guanosine 5′‐monophosphate salt (GMP) in the TRIS buffer. We used electronic circular dichroism and vibrational circular dichroism to describe the thermal response of gels formed by the Guo/GMP binary mixture. Using these complementary techniques suitable to study conformational changes of chiral compounds, we obtained information about the involvement of functional groups and weak interactions in the guanosine quartet (G 4 ) and stacked G 4 structures. Chirality 24:432–438, 2012 . © 2012 Wiley Periodicals, Inc.