Novel Chiral Selector Based on Mefloquine – A Comparative NMR Study to Elucidate Intermolecular Interactions with Acidic Chiral Selectands | Zendy

Kohout Michal | Zendy; Kählig Hanspeter | Zendy; Wolrab Denise | Zendy; Roller Alexander | Zendy; Lindner Wolfgang | Zendy

Premium

Novel Chiral Selector Based on Mefloquine – A Comparative NMR Study to Elucidate Intermolecular Interactions with Acidic Chiral Selectands

Author(s) -

Kohout Michal,

Kählig Hanspeter,

Wolrab Denise,

Roller Alexander,

Lindner Wolfgang

Publication year - 2012

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22029

Subject(s) - chemistry , chirality (physics) , mefloquine , enantiomer , ab initio , computational chemistry , stereochemistry , ab initio quantum chemistry methods , combinatorial chemistry , organic chemistry , molecule , chiral symmetry , physics , quantum mechanics , chloroquine , malaria , nambu–jona lasinio model , immunology , biology , quark

The synthesis, ab initio calculations, and a comparative nuclear magnetic resonance study of a novel chiral mefloquine‐based selector (SO) are presented. On a series of variously N ‐acyl protected leucine selectands (SAs), a feasibility study of mefloquine carbamate as a basic chiral solvating agent, and potential fluorophilic high‐performance liquid chromatography selector has been undertaken and evaluated. An analogy is drawn between the new SO and tert ‐butylcarbamoyl quinidine as a reference. Chirality 24:936–943, 2012 . © 2012 Wiley Periodicals, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research