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Absolute configurations of integracins A, B, and 15′‐dehydroxy‐integracin B
Author(s) -
Liu HaiLi,
Huang XiaoYin,
Li Jia,
Xin GuoRong,
Guo YueWei
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22012
Subject(s) - chemistry , absolute configuration , chirality (physics) , integrase , stereochemistry , cytotoxicity , mangrove , biochemistry , in vitro , gene , chiral symmetry , ecology , physics , quantum mechanics , biology , nambu–jona lasinio model , quark
Integracins A ( 1 ) and B ( 2 ), potent HIV‐1 integrase inhibitors, and 15′‐dehydroxy‐integracin B ( 3 ) were isolated for the first time from Chinese mangrove plant Sonneratia hainanensis . Their absolute configurations were determined by the Mosher's method and specific rotation analysis of alcohols ( 6 and 7 ) obtained from integracin A in two steps and by chemical correlation. Integracin A ( 1 ) also exhibited significant cytotoxicity against the tumor cell lines HepG2 and NCI‐H460 with both 100% inhibitions at 25 µg/ml. Chirality 24:459–462, 2012 . © 2012 Wiley Periodicals, Inc.