Absolute configurations of integracins A, B, and 15′‐dehydroxy‐integracin B | Zendy

Liu HaiLi | Zendy; Huang XiaoYin | Zendy; Li Jia | Zendy; Xin GuoRong | Zendy; Guo YueWei | Zendy

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Absolute configurations of integracins A, B, and 15′‐dehydroxy‐integracin B

Author(s) -

Liu HaiLi,

Huang XiaoYin,

Li Jia,

Xin GuoRong,

Guo YueWei

Publication year - 2012

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.22012

Subject(s) - chemistry , absolute configuration , chirality (physics) , integrase , stereochemistry , cytotoxicity , mangrove , biochemistry , in vitro , gene , chiral symmetry , ecology , physics , quantum mechanics , biology , nambu–jona lasinio model , quark

Integracins A ( 1 ) and B ( 2 ), potent HIV‐1 integrase inhibitors, and 15′‐dehydroxy‐integracin B ( 3 ) were isolated for the first time from Chinese mangrove plant Sonneratia hainanensis . Their absolute configurations were determined by the Mosher's method and specific rotation analysis of alcohols ( 6 and 7 ) obtained from integracin A in two steps and by chemical correlation. Integracin A ( 1 ) also exhibited significant cytotoxicity against the tumor cell lines HepG2 and NCI‐H460 with both 100% inhibitions at 25 µg/ml. Chirality 24:459–462, 2012 . © 2012 Wiley Periodicals, Inc.

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