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Enantioselective disposition of omeprazole, pantoprazole, and lansoprazole in a same Brazilian subjects group
Author(s) -
Cassiano Neila M.,
Oliveira Regina V.,
Bernasconi Gilberto C.R.,
Cass Quezia B.
Publication year - 2012
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.21995
Subject(s) - lansoprazole , omeprazole , pantoprazole , chemistry , proton pump inhibitor , volunteer , pharmacology , enantiomer , cyp2c19 , stereochemistry , medicine , biochemistry , metabolism , cytochrome p450 , agronomy , biology
This work reports the result of the enantioselective disposition of pantoprazole, omeprazole, and lansoprazole in a same group of Brazilian health subjects. Ten nongenotyped healthy subjects were used for this study. Each subject received a single oral dose of 80 mg of pantoprazole, 40 mg of omeprazole, and 30 mg of lansoprazole, and the plasma concentrations of the enantiomers were measured for 8 h postdose. For pantoprazole and omeprazole, among the 10 volunteers investigated, only one volunteer (Subject # 4) presented higher plasma concentrations of the (+)‐enantiomer than those of (−)‐enantiomer. Nevertheless, the area under the concentration–time curve of the (+)‐lansoprazole was higher than those the (−)‐lansoprazole for all subjects. The comparison of proton pump inhibitors' enantiomers disposition from a single group volunteer demonstrated that pantoprazole and omeprazole can be used to differentiate extensive from poor CYP2C19 metabolizer while lansoprazole cannot do it. Chirality, 2012. © 2012 Wiley Periodicals, Inc.