HPLC–CD selectivity assay for alcohol dehydrogenases | Zendy

Hamzic Melissa | Zendy; Pietruszka Jörg | Zendy; Sandkuhl Diana | Zendy

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HPLC–CD selectivity assay for alcohol dehydrogenases

Author(s) -

Hamzic Melissa,

Pietruszka Jörg,

Sandkuhl Diana

Publication year - 2011

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.21025

Subject(s) - chemistry , selectivity , enantioselective synthesis , circular dichroism , alcohol , chirality (physics) , alcohol dehydrogenase , high performance liquid chromatography , chromatography , trimethylsilyl , combinatorial chemistry , organic chemistry , catalysis , stereochemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark

Enantioselective reductions are a key to successful target‐oriented syntheses. Finding the most suitable conditions is often a tedious work that is especially hampered by the time‐consuming analytical investigation. A possible solution is the combined use of high‐performance liquid chromatography and circular dichroism to find a suitable system for providing enantiomerically pure alcohols. This investigation led to an efficient protocol for the alcohol dehydrogenase‐catalyzed reduction of 1‐phenyl‐2‐propyn‐3‐trimethylsilyl‐1‐on ( 1 ). Chirality, 2011. © 2011Wiley Periodicals, Inc.

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