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Preparation and application of methylcalix[4]resorcinarene‐bonded silica particles as chiral stationary phase in high‐performance liquid chromatography
Author(s) -
Tan Huey Min,
Soh Shu Fang,
Zhao Jia,
Yong E. L.,
Gong Yinhan
Publication year - 2011
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20983
Subject(s) - resorcinarene , chemistry , enantiomer , high performance liquid chromatography , chiral column chromatography , chirality (physics) , chromatography , selectivity , fourier transform infrared spectroscopy , stationary phase , phase (matter) , chiral stationary phase , infrared spectroscopy , organic chemistry , catalysis , chemical engineering , molecule , engineering , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Two new types of methylcalix[4]resorcinarene‐bonded stationary phases, (3‐( C ‐methylcalix[4]resorcinarene)‐2‐hydroxypropoxy)‐propylsilyl‐appended silica particles ( MCR‐HPS ) and bromoacetate‐substituted MCR‐HPS particles ( BAMCR‐HPS ), have been synthesized and used as chiral stationary phases for high‐performance liquid chromatography (HPLC) for the first time. The synthetic stationary phases are characterized by means of elemental analysis and Fourier‐transform infrared spectroscopy. The chromatographic behavior of MCR‐HPS and BAMCR‐HPS was studied with several disubstituted benzenes and some chiral drug compounds under both normal phase and reversed‐phase conditions. The results show that MCR‐HPS has excellent selectivity for the separation of aromatic positional isomers and BAMCR‐HPS exhibits excellent performance for separation of enantiomers of chiral compounds. Chirality, 2011. © 2011 Wiley Periodicals, Inc.