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Chiral gas chromatography as a tool for investigations into illicitly manufactured methylamphetamine
Author(s) -
Morrison Calum,
J Smith Frank,
Tomaszewski Tomasz,
Stawiarska Karolina,
Biziuk Marek
Publication year - 2011
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20957
Subject(s) - derivatization , chemistry , enantiomer , ephedrine , chromatography , silylation , pseudoephedrine , reagent , chiral derivatizing agent , gas chromatography , analyte , chirality (physics) , organic chemistry , high performance liquid chromatography , chiral column chromatography , catalysis , chiral symmetry breaking , physics , quantum mechanics , neuroscience , nambu–jona lasinio model , biology , quark
The aim of this study was to develop a chiral gas chromatographic method for the separation of compounds likely to be found in the EMDE synthesis of methylamphetamine, a heavily abused stimulant drug. Here we describe the separation of the enantiomers of ephedrine, pseudoephedrine, chlorinated intermediates and methylamphetamine using fluorinated acid anhydrides as chemical derivatization reagents prior to gas chromatographic analysis on a 2,3‐di‐ O ‐methyl‐6‐ t ‐butyl silyl‐β‐cyclodextrin stationary phase (CHIRALDEX™ B‐DM). Separation of the enantiomers of pseudoephedrine, methylamphetamine and chloro‐intermediates was achieved using PFPA derivatization , and enantiomers of ephedrine using TFAA derivatization , in run times of less than 40 minutes. The use of HFBA as a derivatization reagent for this set of analytes is also discussed. Chirality, 2011. © 2011 Wiley‐Liss, Inc.