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Cu(I)‐catalyzed asymmetric chlorination of β‐keto esters in the presence of chiral phosphine‐schiff base type ligands
Author(s) -
Jiang JiaJun,
Huang Jian,
Wang De,
Yuan ZhiLiang,
Zhao MeiXin,
Wang FeiJun,
Shi Min
Publication year - 2011
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20913
Subject(s) - chemistry , phosphine , schiff base , enantioselective synthesis , ligand (biochemistry) , catalysis , amine gas treating , chirality (physics) , chiral ligand , base (topology) , organic chemistry , medicinal chemistry , axial chirality , polymer chemistry , stereochemistry , receptor , mathematical analysis , biochemistry , mathematics , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Chiral phosphine‐Schiff base type ligand L8 prepared from ( R )‐(−)‐2‐(diphenylphosphino)‐1,1'‐binaphthyl‐2'‐amine was found to be a fairly effective ligand for Cu(I)‐promoted enantioselective chlorination of β‐keto esters to give the corresponding products in high yields and with moderate enantioselectivities. Chirality 2011. © 2010 Wiley‐Liss, Inc.