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The comparison in enantioseparation ability of the chiral stationary phases with single and mixed selector—The selectors derived from two D ‐tartrates
Author(s) -
Chen Jun,
Li MuZi,
Xiao YanHua,
Chen Wei,
Li ShiRong,
Bai ZhengWu
Publication year - 2011
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20904
Subject(s) - chemistry , propanoic acid , tartaric acid , chiral stationary phase , enantiomer , chirality (physics) , chromatography , stereochemistry , organic chemistry , citric acid , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark
(2 S ,3 S )‐2,3‐Bis(3,5‐dimethylphenylcarbonyloxy)‐3‐(benzyloxycarbonyl)‐propanoic acid and (2 S ,3 S )‐2,3‐bis(1‐naphthalenecarbonyloxy)‐3‐(benzyloxycarbonyl)‐propanoic acid were synthesized from D ‐tartaric acid. These two compounds were chlorinated to afford two chiral selectors for chiral stationary phases (CSPs). The selectors were separately immobilized on aminated silica gel to give two single selector CSPs; and were simultaneously immobilized to obtain a mixed selector CSP. Comparing to the single selector CSPs, the mixed selector CSP bears the enhanced enantioseparation ability, suggesting that the two selectors in the mixed selector CSP are consistent for chiral recognition in most mobile phase conditions. Chirality, 2011. © 2010 Wiley‐Liss, Inc.