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High performance liquid chromatography enantioseparation of the novel designed mexiletine derivatives and its analogs
Author(s) -
Zheng Chengzhen,
Zhang Datong,
Wu Qi,
Lin Xianfu
Publication year - 2011
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20880
Subject(s) - chemistry , mexiletine , enantiomer , electrospray ionization , chromatography , mass spectrometry , fourier transform infrared spectroscopy , chirality (physics) , electrospray , fourier transform ion cyclotron resonance , analytical chemistry (journal) , organic chemistry , medicine , physics , quantum mechanics , anesthesia , chiral symmetry breaking , nambu–jona lasinio model , quark
A series of novel designed mexiletine derivatives and its analogs were prepared, the structures were confirmed by Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), and Electrospray Ionization‐Mass Spectrometry (ESI‐MS), and the enantioseparations were performed on polysaccharide‐based chiral stationary phase (CSP), Chiralcel OD‐H, and Chiralcel OJ‐H, under normal‐phase mode. The effects of the concentration of isopropanol in the mobile phase were studied, seven of the eight enantiomers got baseline separation on Chiralcel OD‐H, and five of the eight enantiomers got successfully separation on Chiralcel OJ‐H. The effects of structural features were also discussed. Chirality, 2011. © 2010 Wiley‐Liss, Inc.