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Resolution and absolute configuration assignment of a chiral hemicryptophane molecular cage
Author(s) -
Perraud Olivier,
Raytchev Pascal Dimitrov,
Martinez Alexandre,
Dutasta JeanPierre
Publication year - 2010
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20876
Subject(s) - chemistry , absolute configuration , enantiomer , circular dichroism , cage , chiral stationary phase , resolution (logic) , chiral column chromatography , stereochemistry , chromatography , mathematics , combinatorics , artificial intelligence , computer science
Abstract The racemic hemicryptophane molecular cage 2 was resolved by semipreparative HPLC on Whelk‐O1 column. The absolute configuration of each isolated enantiomer was established from the analysis of their circular dichroism spectra and assigned as P ‐(+)‐ 2 and M ‐(−)‐ 2 . Chirality, 2010. © 2010 Wiley‐Liss, Inc.