Factors influencing the interconversion of a new class of dibenzodiazepine sulfonamide atropisomers | Zendy

Welch Christopher J. | Zendy; Gong Xiaoyi | Zendy; Schafer Wes | Zendy; Chobanian Harry | Zendy; Lin Linus | Zendy; Biba Mirlinda | Zendy; Liu Ping | Zendy; Guo Yan | Zendy; Beard Adam | Zendy

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Factors influencing the interconversion of a new class of dibenzodiazepine sulfonamide atropisomers

Author(s) -

Welch Christopher J.,

Gong Xiaoyi,

Schafer Wes,

Chobanian Harry,

Lin Linus,

Biba Mirlinda,

Liu Ping,

Guo Yan,

Beard Adam

Publication year - 2009

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20785

Subject(s) - atropisomer , chemistry , circular dichroism , ring (chemistry) , stereochemistry , organic chemistry

A novel family of atropisomers based on a conformationally constrained seven membered ring system is investigated using a combination of preparative chiral chromatography, circular dichroism, and other analytical techniques. The influence of structure on the rate of atropisomer interconversion was explored with a series of analogs showing a range of interconversion rates ranging from very fast (undetectable on the HPLC timescale) to very slow (half life of many days). Chirality 21:E105–E109, 2009. © 2009 Wiley‐Liss, Inc.

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