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Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer
Author(s) -
Anderson Marcus,
Wilcox Katie,
Guericke Mike,
Chu Han,
Wilson Mark V.,
Wilson Erin,
Lucas Kerry,
Holmes Andrea E.
Publication year - 2009
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20752
Subject(s) - chemistry , porphyrin , circular dichroism , enantiomer , methamphetamine , stereochemistry , photochemistry , medicine
Using exciton‐coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host–guest complex formed with (+)‐( S )‐methamphetamine produced a negative bisignate‐shaped ECCD spectrum, whereas the complex formed with (−)‐( R )‐methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States. Chirality 2010. © 2009 Wiley‐Liss, Inc.