Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer | Zendy

Anderson Marcus | Zendy; Wilcox Katie | Zendy; Guericke Mike | Zendy; Chu Han | Zendy; Wilson Mark V. | Zendy; Wilson Erin | Zendy; Lucas Kerry | Zendy; Holmes Andrea E. | Zendy

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Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer

Author(s) -

Anderson Marcus,

Wilcox Katie,

Guericke Mike,

Chu Han,

Wilson Mark V.,

Wilson Erin,

Lucas Kerry,

Holmes Andrea E.

Publication year - 2009

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20752

Subject(s) - chemistry , porphyrin , circular dichroism , enantiomer , methamphetamine , stereochemistry , photochemistry , medicine

Using exciton‐coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host–guest complex formed with (+)‐( S )‐methamphetamine produced a negative bisignate‐shaped ECCD spectrum, whereas the complex formed with (−)‐( R )‐methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States. Chirality 2010. © 2009 Wiley‐Liss, Inc.

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