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Parallel kinetic resolution of D ‐labelled 2‐aryl‐propionic and butanoic acids using quasi ‐enantiomeric combinations of oxazolidin‐2‐ones
Author(s) -
Coulbeck Elliot,
Dingjan Marco,
Eames Jason
Publication year - 2010
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20727
Subject(s) - chemistry , enantiomer , kinetic resolution , yield (engineering) , aryl , chirality (physics) , enantiomeric excess , resolution (logic) , kinetic energy , stereochemistry , organic chemistry , catalysis , enantioselective synthesis , chiral symmetry , thermodynamics , physics , alkyl , nambu–jona lasinio model , quantum mechanics , artificial intelligence , quark , computer science
The parallel kinetic resolution of racemic 2‐aryl‐2‐deuterio‐propionic and butanoic acids using an equimolar combination of quasi ‐enantiomeric oxazolidin‐2‐ones is discussed. The levels of diastereoselectivity were high leading to enantiomerically pure D ‐labeled products in good yield. Chirality, 2010. © 2009 Wiley‐Liss, Inc.