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Ligand binding strategies of human serum albumin: How can the cargo be utilized?
Author(s) -
Varshney Ankita,
Sen Priyankar,
Ahmad Ejaz,
Rehan Mohd.,
Subbarao Naidu,
Khan Rizwan Hasan
Publication year - 2010
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20709
Subject(s) - chemistry , human serum albumin , albumin , prodrug , ligand (biochemistry) , drug delivery , computational biology , drug , small molecule , function (biology) , serum albumin , plasma protein binding , biochemistry , combinatorial chemistry , pharmacology , microbiology and biotechnology , receptor , biology , organic chemistry
Human serum albumin (HSA), being the most abundant carrier protein in blood and a modern day clinical tool for drug delivery, attracts high attention among biologists. Hence, its unfolding/refolding strategies and exogenous/endogenous ligand binding preference are of immense use in therapeutics and clinical biochemistry. Among its fellow proteins albumin is known to carry almost every small molecule. Thus, it is a potential contender for being a molecular cargo/or nanovehicle for clinical, biophysical and industrial purposes. Nonetheless, its structure and function are largely regulated by various chemical and physical factors to accommodate HSA to its functional purpose. This multifunctional protein also possesses enzymatic properties which may be used to convert prodrugs to active therapeutics. This review aims to highlight current overview on the binding strategies of protein to various ligands that may be expected to lead to significant clinical applications. Chirality, 2010. © 2009 Wiley‐Liss, Inc.