Synthesis and optical resolution of 1‐[(3‐carboxy‐1,1′‐biphenyl)‐2‐yl]‐ 1H ‐pyrrole‐2‐carboxylic acid | Zendy

Faigl Ferenc | Zendy; VasFeldhoffer Bernadett | Zendy; Kudar Veronika | Zendy; Czugler Mátyás | Zendy; Pál Krisztina | Zendy; Kubinyi Miklós | Zendy

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Synthesis and optical resolution of 1‐[(3‐carboxy‐1,1′‐biphenyl)‐2‐yl]‐ 1H ‐pyrrole‐2‐carboxylic acid

Author(s) -

Faigl Ferenc,

VasFeldhoffer Bernadett,

Kudar Veronika,

Czugler Mátyás,

Pál Krisztina,

Kubinyi Miklós

Publication year - 2009

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20686

Subject(s) - chemistry , pyrrole , biphenyl , enantiomer , chirality (physics) , carboxylic acid , absolute configuration , resolution (logic) , stereochemistry , single crystal , medicinal chemistry , crystallography , organic chemistry , chiral symmetry , physics , quantum mechanics , artificial intelligence , computer science , nambu–jona lasinio model , quark

Site selective mono‐ and dimetalation methods have been developed for the functionalization of 1‐[(1,1′‐biphenyl)‐2‐yl]‐1H‐pyrrole. Optical resolution of the prepared 1‐[(3‐carboxy‐1,1′‐biphenyl)‐2‐yl]pyrrole‐2‐carboxylic acid provided new atropisomeric 1‐arylpyrrole derivatives. The absolute configuration of the pure dicarboxylic acid enantiomers was determined by single crystal X‐ray diffraction and CD spectroscopy. Chirality 2009. © 2009 Wiley‐Liss, Inc.

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