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Asymmetric Friedel‐Crafts alkylations of indoles with dialkyl 3‐oxoprop‐1‐enylphosphonates: Organocatalytic enantioselective synthesis of α‐indolyl phosphonates
Author(s) -
Guo YingCen,
Li DongPing,
Li YuLing,
Wang HongMei,
Xiao WenJing
Publication year - 2009
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20679
Subject(s) - enantioselective synthesis , chemistry , friedel–crafts reaction , yield (engineering) , organocatalysis , chirality (physics) , alkylation , organic chemistry , stereochemistry , catalysis , materials science , chiral symmetry breaking , physics , quantum mechanics , quark , nambu–jona lasinio model , metallurgy
Organocatalytic enantioselective synthesis of α‐indolyl phosphonates has been successfully carried out via asymmetric Friedel‐Crafts alkylation of substituted indoles with ( E )‐dialkyl 3‐oxoprop‐1‐enylphosphonates in 48–82% yield and 73–96% ee. Chirality, 2009. © 2008 Wiley‐Liss, Inc.