Asymmetric Friedel‐Crafts alkylations of indoles with dialkyl 3‐oxoprop‐1‐enylphosphonates: Organocatalytic enantioselective synthesis of α‐indolyl phosphonates | Zendy

Guo YingCen | Zendy; Li DongPing | Zendy; Li YuLing | Zendy; Wang HongMei | Zendy; Xiao WenJing | Zendy

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Asymmetric Friedel‐Crafts alkylations of indoles with dialkyl 3‐oxoprop‐1‐enylphosphonates: Organocatalytic enantioselective synthesis of α‐indolyl phosphonates

Author(s) -

Guo YingCen,

Li DongPing,

Li YuLing,

Wang HongMei,

Xiao WenJing

Publication year - 2009

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20679

Subject(s) - enantioselective synthesis , chemistry , friedel–crafts reaction , yield (engineering) , organocatalysis , chirality (physics) , alkylation , organic chemistry , stereochemistry , catalysis , materials science , chiral symmetry breaking , physics , quantum mechanics , quark , nambu–jona lasinio model , metallurgy

Organocatalytic enantioselective synthesis of α‐indolyl phosphonates has been successfully carried out via asymmetric Friedel‐Crafts alkylation of substituted indoles with ( E )‐dialkyl 3‐oxoprop‐1‐enylphosphonates in 48–82% yield and 73–96% ee. Chirality, 2009. © 2008 Wiley‐Liss, Inc.

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