Application of kinetic resolution using HCS as chiral auxiliary: Novel synthesis of β‐blockers ( S )‐betaxolol and ( S )‐metoprolol | Zendy

Zhang JingYu | Zendy; Liu HongMin | Zendy; Wang XiaoJun | Zendy; Wang Pei | Zendy; Zheng JiaXin | Zendy

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Application of kinetic resolution using HCS as chiral auxiliary: Novel synthesis of β‐blockers ( S )‐betaxolol and ( S )‐metoprolol

Author(s) -

Zhang JingYu,

Liu HongMin,

Wang XiaoJun,

Wang Pei,

Zheng JiaXin

Publication year - 2009

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20674

Subject(s) - chemistry , betaxolol , kinetic resolution , metoprolol , enantiomer , chirality (physics) , chiral auxiliary , resolution (logic) , combinatorial chemistry , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , timolol , intraocular pressure , medicine , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , artificial intelligence , quark , computer science , cardiology , ophthalmology

Optically pure ( S )‐betaxolol and ( S )‐metoprolol were prepared with an extremely facile and practical method using kinetic resolution of β‐amino alcohols employing HCS as chiral auxiliary. High enantiomeric purity (ee > 99%) was achieved and the synthetic strategy is amenable to industrial scale‐up. Chirality, 2009. © 2008 Wiley‐Liss, Inc.

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