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Potential of different techniques of preferential crystallization for enantioseparation of racemic compound forming systems
Author(s) -
Polenske Daniel,
Lorenz Heike,
SeidelMorgenstern Andreas
Publication year - 2009
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20672
Subject(s) - crystallization , chemistry , mandelic acid , enantiomer , chirality (physics) , isothermal process , racemic mixture , chemical engineering , crystallography , thermodynamics , organic chemistry , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , engineering , quark
Recently the feasibility of preferential crystallization for enantioseparation of racemic compound forming systems has been demonstrated (Lorenz et al., Application of preferential crystallization to resolve racemic compounds in a hybrid process. Chirality 2006;18:828–840; Polenske et al., Separation of the propranolol hydrochloride enantiomers by preferential crystallization: thermodynamic basis and experimental verification. Cryst Growth Des 2007;7:1628–1634). Here, the development and the potential of an efficient separation process operated via two different techniques of preferential crystallization are studied: (1) seeded isothermal preferential crystallization and (2) auto‐seeded polythermal preferential crystallization. Both techniques were investigated in the batch and in the cyclic operation mode. On the example of mandelic acid as a typical racemic compound forming system, it is demonstrated that a cyclic auto‐seeded polythermal process is feasible and significantly more efficient than the seeded isothermal one. Chirality, 2009. © 2008 Wiley‐Liss, Inc.