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Enantiomeric separation of chiral ruthenium(II) complexes using capillary electrophoresis
Author(s) -
Jiang Chunxia,
Tong ManYung,
Armstrong Daniel W.,
Perera Sirantha,
Bao Ye,
MacDonnell Frederick M.
Publication year - 2009
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20641
Subject(s) - ruthenium , chemistry , capillary electrophoresis , diimine , enantiomer , tris , cyclodextrin , electrophoresis , chromatography , organic chemistry , catalysis , biochemistry
Capillary zone electrophoresis (CZE) and micellar capillary electrophoresis (MCE) were applied for the enantiomeric separation of nine mononuclear tris(diimine)ruthenium(II) complexes as well as the separation of all stereoisomers of a dinuclear tris(diimine)ruthenium(II) complex. Nine cyclodextrin (CD) based chiral selectors were examined as run buffer additives to evaluate their effectiveness in the enantiomeric separation of tris(diimine)ruthenium(II) complexes. Seven showed enantioselectivity. Sulfated γ‐cyclodextrin (SGC), with four baseline and three partial separations, was found to be the most useful chiral selector. In CZE mode, the derivatized γ‐CDs were more effective than β‐CDs while sulfated CDs work better than carboxymethyl CDs. In MCE mode, hydroxypropyl β‐CD separated the greatest number of tris(diimine) ruthenium(II) complexes. The effects of chiral selector concentration, run buffer pH and concentration, the concentration ratio between chiral selector and other factors were investigated. Chirality, 2009. © 2008 Wiley‐Liss, Inc.