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Chemoenzymatic and microbial dynamic kinetic resolutions
Author(s) -
Kamaruddin Azlina Harun,
Uzir Mohamad Hekarl,
AboulEnein Hassan Y.,
Halim Hairul Nazirah Abdul
Publication year - 2009
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20619
Subject(s) - kinetic resolution , racemization , chemistry , chirality (physics) , biochemical engineering , biocatalysis , kinetic energy , resolution (logic) , nanotechnology , combinatorial chemistry , enantioselective synthesis , organic chemistry , catalysis , reaction mechanism , artificial intelligence , materials science , quantum mechanics , chiral symmetry breaking , physics , quark , computer science , nambu–jona lasinio model , engineering
This review tracks a decade of dynamic kinetic resolution developments with a biocatalytic inclination using enzymatic/microbial means for the resolution part followed by the racemization reactions either by means of enzymatic or chemocatalyst. These fast developments are due to the ability of the biocatalysts to significantly reduce the number of synthetic steps which are common for conventional synthesis. Future developments in novel reactions and products of dynamic kinetic resolutions should consider factors that are needed to be extracted at the early synthetic stage to avoid inhibition at scale‐up stage have been highlighted. Chirality, 2009. © 2008 Wiley‐Liss, Inc.