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Asymmetric aldol reactions catalyzed by efficient and recyclable silica‐supported proline‐based peptides
Author(s) -
Yan Jincan,
Wang Lei
Publication year - 2009
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20603
Subject(s) - chemistry , aldol reaction , proline , catalysis , acetone , enantiomer , filtration (mathematics) , reactivity (psychology) , chirality (physics) , organic chemistry , enantioselective synthesis , intermolecular force , organocatalysis , enantiomeric excess , combinatorial chemistry , peptide , molecule , amino acid , biochemistry , medicine , statistics , alternative medicine , mathematics , chiral symmetry breaking , pathology , quantum mechanics , physics , nambu–jona lasinio model , quark
A series of silica‐supported proline‐based peptides were synthesized and applied as catalysts for direct asymmetric intermolecular aldol reactions. Among these, a peptide with two L ‐proline units was found to be the most efficient one for the asymmetric aldol reactions between acetone and aromatic aldehydes. The reactions generated the corresponding products with satisfactory isolated yields (up to 97%) and enantiomeric excesses (up to 96%) in the presence of this catalyst (5 mol %). Furthermore, the silica‐supported organocatalyst could be recovered and recycled by a simple filtration of the reaction solution and used for five consecutive trials without loss of its reactivity. Chirality, 2009. © 2008 Wiley‐Liss, Inc.