Premium
Enantioselective cyanosilylation of ketones catalyzed by recyclable polymeric and dimeric MN(III) salen complexes at room temperature
Author(s) -
Khan NoorUl H.,
Agrawal Santosh,
Kureshy Rukhsana I.,
Abdi Sayed H.R.,
Prathap K. Jeya,
Jasra Raksh V.
Publication year - 2009
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20534
Subject(s) - chemistry , enantioselective synthesis , cyanohydrin , catalysis , enantiomeric excess , enantiomer , chirality (physics) , trimethylsilyl , organic chemistry , reactivity (psychology) , polymer chemistry , hydrosilylation , medicinal chemistry , medicine , chiral symmetry breaking , physics , alternative medicine , pathology , quantum mechanics , quark , nambu–jona lasinio model
Recyclable polymeric 1 and dimeric 2 chiral Mn(III) salen complexes catalyzed enantioselective cyanosilylation of various ketones in the presence of triphenylphosphine oxide as an additive proceeded smoothly at room temperature, providing excellent yields (up to 98%) and enantiomeric excess (up to 86%) of respective cyanohydrin trimethylsilyl ether. For most of the substrates, the Catalyst 1 showed slightly better reactivity and enantioselecitivity than the Catalyst 2 nevertheless both the catalysts were easily recovered and reused four times with the retention of their efficiency. Chirality, 2009. © 2008 Wiley‐Liss, Inc.