Enantioselective cyanosilylation of ketones catalyzed by recyclable polymeric and dimeric MN(III) salen complexes at room temperature | Zendy

Khan NoorUl H. | Zendy; Agrawal Santosh | Zendy; Kureshy Rukhsana I. | Zendy; Abdi Sayed H.R. | Zendy; Prathap K. Jeya | Zendy; Jasra Raksh V. | Zendy

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Enantioselective cyanosilylation of ketones catalyzed by recyclable polymeric and dimeric MN(III) salen complexes at room temperature

Author(s) -

Khan NoorUl H.,

Agrawal Santosh,

Kureshy Rukhsana I.,

Abdi Sayed H.R.,

Prathap K. Jeya,

Jasra Raksh V.

Publication year - 2009

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20534

Subject(s) - chemistry , enantioselective synthesis , cyanohydrin , catalysis , enantiomeric excess , enantiomer , chirality (physics) , trimethylsilyl , organic chemistry , reactivity (psychology) , polymer chemistry , hydrosilylation , medicinal chemistry , medicine , chiral symmetry breaking , physics , alternative medicine , pathology , quantum mechanics , quark , nambu–jona lasinio model

Recyclable polymeric 1 and dimeric 2 chiral Mn(III) salen complexes catalyzed enantioselective cyanosilylation of various ketones in the presence of triphenylphosphine oxide as an additive proceeded smoothly at room temperature, providing excellent yields (up to 98%) and enantiomeric excess (up to 86%) of respective cyanohydrin trimethylsilyl ether. For most of the substrates, the Catalyst 1 showed slightly better reactivity and enantioselecitivity than the Catalyst 2 nevertheless both the catalysts were easily recovered and reused four times with the retention of their efficiency. Chirality, 2009. © 2008 Wiley‐Liss, Inc.

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