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Enantioseparation of 2‐aryl‐1,3‐dicarbonyl analogues by high performance liquid chromatography using polysaccharide type chiral stationary phase
Author(s) -
Xu Zhe,
Ding Zuoding,
Xu Xu,
Xie Xiaoan
Publication year - 2008
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20513
Subject(s) - chemistry , aryl , amylose , tris , chirality (physics) , cellulose , chiral derivatizing agent , chiral column chromatography , high performance liquid chromatography , carbamate , organic chemistry , chromatography , biochemistry , alkyl , chiral symmetry breaking , physics , quantum mechanics , starch , nambu–jona lasinio model , quark
The HPLC chiral separation of 21 kinds of 2‐aryl‐1,3‐dicarbonyl analogues was investigated in normal phase mode with amylose tris(3,5‐dimethylphenylcarbamate), amylose tris(( S )‐1‐phenylethylcarbamate), cellulose tris(3,5‐dimethylphenylcarbamate), and cellulose tris(4‐methylbenzoate) chiral stationary phases, respectively. The whole set of 2‐aryl‐1,3‐dicarbonyl analogues shows better enantioselectivity and enantioseparation on amylose tris(3,5‐dimethylphenyl carbamate) (Chiralpak AD‐H). The temperature dependence of enantioselectivity was studied to improve the enantioseparation. In addition, efforts are made to relate analyte structure with the quality of the achieved chiral separation. Chirality, 2008. © 2007 Wiley‐Liss, Inc.