Premium
Fluorous “racemic” mixture synthesis: Polysaccharide‐based chiral columns for simultaneous demix and enantioseparation of racemic fluorous tagged compounds
Author(s) -
Tonoi Takayuki,
Zhang Wei,
Curran Dennis P.,
Mikami Koichi
Publication year - 2008
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20487
Subject(s) - chemistry , enantiomer , polysaccharide , chiral column chromatography , racemic mixture , chiral stationary phase , organic chemistry , chiral derivatizing agent , chromatography
Abstract The proof of concept experiments of fluorous “racemic” mixture synthesis (FRMS) is shown using polysaccharide‐based chiral stationary phases. The mixture of racemic O ‐benzoylmandelate derivatives bearing different lengths of fluorous cleavable tags undergoes sequential reactions to provide individual derivatives as well as their enantiomers resolved on polysaccharide‐based chiral HPLC columns (DAICEL CHIRALCEL® and CHIRALPAK® series). Chirality, 2008. © 2008 Wiley‐Liss, Inc.