Fluorous “racemic” mixture synthesis: Polysaccharide‐based chiral columns for simultaneous demix and enantioseparation of racemic fluorous tagged compounds | Zendy

Tonoi Takayuki | Zendy; Zhang Wei | Zendy; Curran Dennis P. | Zendy; Mikami Koichi | Zendy

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Fluorous “racemic” mixture synthesis: Polysaccharide‐based chiral columns for simultaneous demix and enantioseparation of racemic fluorous tagged compounds

Author(s) -

Tonoi Takayuki,

Zhang Wei,

Curran Dennis P.,

Mikami Koichi

Publication year - 2008

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20487

Subject(s) - chemistry , enantiomer , polysaccharide , chiral column chromatography , racemic mixture , chiral stationary phase , organic chemistry , chiral derivatizing agent , chromatography

The proof of concept experiments of fluorous “racemic” mixture synthesis (FRMS) is shown using polysaccharide‐based chiral stationary phases. The mixture of racemic O ‐benzoylmandelate derivatives bearing different lengths of fluorous cleavable tags undergoes sequential reactions to provide individual derivatives as well as their enantiomers resolved on polysaccharide‐based chiral HPLC columns (DAICEL CHIRALCEL® and CHIRALPAK® series). Chirality, 2008. © 2008 Wiley‐Liss, Inc.

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