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Why is it important to simultaneously use more than one chiroptical spectroscopic method for determining the structures of chiral molecules?
Author(s) -
Polavarapu Prasad L.
Publication year - 2007
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20475
Subject(s) - raman optical activity , circular dichroism , chemistry , chirality (physics) , vibrational circular dichroism , optical rotatory dispersion , molecule , raman spectroscopy , computational chemistry , chemical physics , crystallography , chiral symmetry , optics , organic chemistry , quantum mechanics , physics , nambu–jona lasinio model , quark
In recent years, four different chiroptical spectroscopic methods, namely vibrational circular dichroism, vibrational Raman optical activity, electronic circular dichroism, and optical rotatory dispersion, have become popular for establishing the absolute configuration and predominant conformations of chiral molecules in solution state. Many individual laboratories normally utilize only one of these methods to derive the molecular structural information. Although that approach may be satisfactory for most of the molecules studied, it is to be noted that in some instances a single method can give ambiguous conclusions or may not give complete structural information. This article summarizes the situations where simultaneous use of more than one chiroptical spectroscopic method is required to obtain molecular structural information and recommends the routine application of more than one chiroptical spectroscopic method for any given molecule. Chirality, 2008. © 2007 Wiley‐Liss, Inc.