Premium
Supramolecular tilt chirality in crystals of steroids and alkaloids
Author(s) -
Hisaki Ichiro,
Tohnai Norimitsu,
Miyata Mikiji
Publication year - 2008
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20443
Subject(s) - chirality (physics) , supramolecular chemistry , chemistry , stereocenter , axial chirality , supramolecular chirality , context (archaeology) , molecule , stereochemistry , crystal engineering , crystallography , nanotechnology , enantioselective synthesis , organic chemistry , physics , materials science , paleontology , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , biology , quark , catalysis
The concept of supramolecular chirality has assumed increasing importance in association with the development of supramolecular chemistry over the last two decades. In chiral crystals, 2 1 helical molecular assemblies are frequently observed as key motifs. Helical handedness of the 2 1 assemblies, however, has not been determined from the mathematical or crystallographical viewpoints. In this context, we have proposed two new concepts, three‐axial chirality and tilt chirality. On the basis of the concepts, we describe supramolecular chirality and determine the handedness of 2 1 assemblies that are composed of relatively complicated molecules with multiple stereogenic centers such as brucine, bile acids, and cinchona alkaloids as well as those of simple molecules. Chirality, 2008. © 2007 Wiley‐Liss, Inc.