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Investigation of the stability of Chiralpak AD chiral stationary phase under various solvent conditions and development of a method to identify stationary phase‐derived polymer contamination
Author(s) -
Welch Christopher J.,
Fairchild Jacob,
Sajonz Peter
Publication year - 2007
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20348
Subject(s) - chemistry , solvent , chiral stationary phase , stationary phase , solubilization , polymer , chirality (physics) , phase (matter) , contamination , carbamate , chromatography , analytical chemistry (journal) , organic chemistry , ecology , biochemistry , chiral symmetry breaking , physics , quantum mechanics , quark , nambu–jona lasinio model , biology
The stability of Chiralpak AD chiral stationary phase under various solvent conditions was investigated. An analytical method for the detection of the presence of solubilized Chiralpak AD coating was developed using CD spectroscopy (CD signal at 245 nm). In addition, NMR analysis of the solubilized polymer revealed a characteristic signal for the 3,5‐dimethylphenyl carbamate methyl protons at around 2.5 ppm. Both of these methods may be helpful in detecting contamination by the Chiralpak AD polymer or in the study of CSP solvent compatibility. Chirality 19:607–611, 2006 © 2006 Wiley‐Liss, Inc.