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Fast methods of enantiopurity determination for the Soai reaction: Towards a general enantioenrichment detector?
Author(s) -
Welch Christopher J.,
Biba Mirlinda,
Sajonz Peter
Publication year - 2006
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20336
Subject(s) - chemistry , enantioselective synthesis , chirality (physics) , autocatalysis , chromatography , detector , supercritical fluid , circular dichroism , combinatorial chemistry , stereochemistry , catalysis , organic chemistry , physics , optics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
The Soai reaction system possesses a remarkable combination of characteristics (enantioselective autocatalysis, strong positive nonlinearity leading to asymmetric amplification, ability to be triggered by wide variety of exogenous enantioenriched materials) that make it a potential starting point for a generalized detector for enantioenrichment. In this study we apply standard approaches used in pharmaceutical process research to the problem of developing a rapid method for analysis of the enantiopurity of the Soai reaction product. Several methods for rapid analysis (<1 min per sample) are described, including an approach using chiral supercritical fluid chromatography (SFC) and an approach using achiral chromatography with circular dichroism (CD) detection. Some thoughts on incorporation into a device for generalized enantioenrichment detection are presented. Chirality, 2006. © 2006 Wiley‐Liss, Inc.