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Synthesis of polymer‐type chiral stationary phases and their enantioseparation evaluation by high‐performance liquid chromatography
Author(s) -
Huang ShaoHua,
Bai ZhengWu,
Yin ChuanQi,
Li ShiRong,
Pan ZhiQuan
Publication year - 2007
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20324
Subject(s) - chemistry , polymer , chiral column chromatography , copolymer , high performance liquid chromatography , chiral derivatizing agent , enantiomer , side chain , enantioselective synthesis , phase (matter) , organic chemistry , chromatography , polymer chemistry , catalysis
Two new chiral polymers of different molecular weights were synthesized by the copolymerization of (1 R ,2 R )‐(+)‐1,2‐diphenylethylenediamine, phenyl diisocyanate and terephthaloyl chloride. The polymers were immobilized on aminated silica gel to afford two chiral stationary phases. The polymers and the corresponding chiral stationary phases were characterized by Fourier transform‐IR, elemental analysis, 1 H and 13 C NMR. The surface coverages of chiral structural units on the chiral stationary phases were estimated as 0.27 and 0.39 mmol/g, respectively. The enantioseparation ability of these chiral stationary phases was evaluated with a variety of chiral compounds by high‐performance liquid chromatography. The effects of the organic additives, the composition of mobile phases, and the injection amount of sample on enantioseparation were investigated. A comparison of enantioseparation ability between these two chiral stationary phases was made. It was believed that the chain length of polymeric chiral selector significantly affected the enantioseparation ability of corresponding chiral stationary phase. Chirality, 2007. © 2006 Wiley‐Liss, Inc.