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Semipreparative enantioseparation of Tröger base derivatives by HPLC
Author(s) -
Sergeyev Sergey,
Diederich François
Publication year - 2006
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20318
Subject(s) - chemistry , enantiopure drug , high performance liquid chromatography , chromatography , base (topology) , cellulose , combinatorial chemistry , catalysis , organic chemistry , enantioselective synthesis , mathematical analysis , mathematics
We describe the enantioseparation of functionalized derivatives of the Tröger base by HPLC on commercially available chiral stationary phases. Cellulose‐derived Chiralcel OJ and brush‐type Whelk O1 are demonstrated to be complementary to each other in their scope. On the basis of the results obtained, the separation of selected compounds was successfully transferred onto semipreparative columns. We believe that the availability of enantiopure functionalized derivatives of the Tröger base will stimulate the further use of this interesting molecular scaffold in molecular recognition, asymmetric catalysis, and related areas of research and technology. Chirality, 2006. © 2006 Wiley‐Liss, Inc.