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β‐cyclodextrin‐immobilized (4 S )‐phenoxy‐( S )‐proline as a catalyst for direct asymmetric aldol reactions
Author(s) -
Shen Zongxuan,
Ma Jimei,
Liu Yanhua,
Jiao Chongjun,
Li Ming,
Zhang Yawen
Publication year - 2005
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20208
Subject(s) - chemistry , aldol reaction , proline , catalysis , cyclodextrin , solvent , ethanol , organocatalysis , organic chemistry , enantioselective synthesis , beta (programming language) , beta cyclodextrins , amino acid , biochemistry , computer science , programming language
Abstract β‐Cyclodextrin‐immobilized (4 S )‐phenoxy‐( S )‐proline was prepared conveniently by simply heating the amino acid and β‐cyclodextrin in ethanol–water (1/1, v/v) and removal of the solvent. This proved to be an efficient catalyst for direct asymmetric aldol reactions, and the catalyst could be recycled four times without loss of enantioselectivity. © 2005 Wiley‐Liss, Inc. Chirality 17:556–558, 2005.