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Cationic cobalt(I) catalysts for the asymmetric cyclocarbonylation of 1,6‐enynes
Author(s) -
Schmid Thomas M.,
Gischig Sebastian,
Consiglio Giambattista
Publication year - 2005
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20173
Subject(s) - chemistry , catalysis , cobalt , cationic polymerization , diphenylphosphine , enantioselective synthesis , chirality (physics) , ligand (biochemistry) , medicinal chemistry , stereoselectivity , stereochemistry , polymer chemistry , organic chemistry , receptor , phosphine , biochemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Cobalt(I) complexes, modified with ( R )‐(6,6′‐dimethoxybiphenyl‐2,2′‐diyl)bis(diphenylphosphine) [Co(( R )‐MeO‐Biphep)(CO) 3 ]X (X = BF 4 [ 1 ] or OTf [ 2 ]), were synthesized and characterized. The compounds have a trigonal bipyramidal structure and are fluxional. They were tested as catalyst precursors for the enantioselective cyclocarbonylation of 4,4‐bis(carboethoxy)hept‐5‐en‐1‐yne 3. Enantioselectivities up to 78.5% were attained. However, activity and stereoselectivity are lower compared to catalytic systems based on Co 2 (CO) 8 modified with the same atropisomeric ligand. Chirality 17:353–356, 2005. © 2005 Wiley‐Liss, Inc.