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Enantiopure drug synthesis: From methyldopa to imipenem to efavirenz
Author(s) -
Grabowski Edward J.J.
Publication year - 2005
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20143
Subject(s) - enantiopure drug , chirality (physics) , chemistry , efavirenz , axial chirality , section (typography) , stereochemistry , presentation (obstetrics) , combinatorial chemistry , enantioselective synthesis , organic chemistry , virology , computer science , catalysis , surgery , nuclear physics , physics , medicine , chiral symmetry breaking , human immunodeficiency virus (hiv) , quark , antiretroviral therapy , viral load , nambu–jona lasinio model , biology , operating system
An historical retrospective is presented relative to the development of practical processes for the syntheses of three major drugs: methyldopa, imipenem, and efavirenz. Each highlights a major method for asymmetric synthesis. This work was initially presented as a lecture at the BLOCKBUSTER CHIRALITY section of the CHIRALITY 2004 meeting in New York City, and this paper is simply a written account of that presentation. The original literature that details the chemistry discussed herein is noted in the reference section. Chirality 17:S249–S259, 2005. © 2005 Wiley‐Liss, Inc.
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