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Contributions to the theory and practice of the chromatographic separation of enantiomers
Author(s) -
Schurig Volker
Publication year - 2005
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20133
Subject(s) - enantioselective synthesis , chemistry , enantiomer , chromatography , gas chromatography , organic chemistry , catalysis
The theory and practice of enantioselective capillary chromatography employing metal coordination compounds and modified cyclodextrins as chiral stationary phases are treated. A unified approach involving all contemporary chromatographic methods and a single enantioselective column is described. Reliable thermodynamic data of enantioselectivity are derived by the retention‐increment method. The existence of an isoenantioselective temperature is demonstrated. Kinetic enantiomerization studies are presented. The preparative‐scale separation of enantiomers by gas chromatography with enantioselective packed columns is achieved. Unusual phenomena and future aspects of enantioselective chromatography are discussed. Chirality 17:S205–S226, 2005. © 2005 Wiley‐Liss, Inc.