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Enantioseparation of the esters of α‐ N ‐acetyl amino acids by lipase in ionic liquid
Author(s) -
Malhotra Sanjay V.,
Zhao Hua
Publication year - 2005
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20132
Subject(s) - chemistry , lipase , ionic liquid , organic chemistry , amino acid , chromatography , enzyme , biochemistry , catalysis
Chiral α‐amino acids have been obtained via enzymatic resolution in ionic liquid medium. The acetyl esters of a series of amino acids were separated by enzyme porcine pancreas lipase (PPL) in an aqueous solution of N ‐ethyl pyridinium trifluoroacetate, [EtPy] + [CF 3 OO] − . A comparative study with organic solvent acetonitrile shows that the ionic liquids provide a better medium for enzymatic resolution. Chirality 17:S240–S242, 2005. © 2005 Wiley‐Liss, Inc.