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Bile acid derivatives as enantiodifferentiating host molecules in inclusion processes
Author(s) -
Bortolini Olga,
Fantin Giancarlo,
Fogagnolo Marco
Publication year - 2005
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20126
Subject(s) - chemistry , chirality (physics) , enantioselective synthesis , inclusion (mineral) , host (biology) , molecule , bile acid , organic chemistry , stereochemistry , biochemistry , catalysis , ecology , mineralogy , biology , physics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
A review on the use of bile acids as hosts for molecular recognition and enantioresolution is presented. The optical resolution of different classes of organic derivatives, i.e., lactones, aliphatic alcohols, sulfoxides, epoxides, ketones, cyclic amides, cyclic carbonates, and sulfites, may be obtained by host–guest enantioselective inclusion complexation. The salient aspects of the enclathration process, including X‐ray diffraction results, are discussed. Chirality 17:121–130, 2005. © 2005 Wiley‐Liss, Inc.