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Synthesis of latanoprost diastereoisomers
Author(s) -
Obadalová Iva,
Pilarčík Tomáš,
Slavíková Markéta,
Hájíček Josef
Publication year - 2005
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20116
Subject(s) - diastereomer , chemistry , stereoselectivity , chirality (physics) , stereochemistry , latanoprost , lactone , organic chemistry , catalysis , chiral symmetry , medicine , glaucoma , ophthalmology , physics , quantum mechanics , nambu–jona lasinio model , quark
A new synthesis of latanoprost diastereoisomers is described which utilizes a highly stereoselective Michael addition of higher‐order cuprate to a chiral cyclopentenone derived from G‐lactone in the crucial skeleton‐forming step. Chirality 17:S109–S113, 2005. © 2005 Wiley‐Liss, Inc.