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Enantioselective synthesis of 2‐ and 3‐substituted 2,3‐dihydro[1,4]dioxino[2,3‐ b ]pyridine derivatives and enantiomeric purity control by capillary electrophoresis
Author(s) -
Lazar S.,
Soukri M.,
El Haddad M.,
Akssira M.,
Leger J.M.,
Jarry C.,
Morin Ph.,
Guillaumet G.
Publication year - 2004
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20090
Subject(s) - chemistry , capillary electrophoresis , enantioselective synthesis , enantiomer , pyridine , formic acid , chromatography , cyclodextrin , enantiomeric excess , organic chemistry , catalysis
A rapid and simple procedure for enantioselective preparation of 2‐ and 3‐substituted 2,3‐dihydro[1,4]dioxino[2,3‐ b ]pyridine derivatives ( A and B , respectively) is described. The enantiomeric purity of each isomer was determined by capillary electrophoresis using a dual‐cyclodextrin system ( S ‐β‐CD/β‐CD) dissolved in formic acid–ammonia buffer (pH 4, ionic strength 50 mM). Chirality 17:30–36, 2005. © 2004 Wiley‐Liss, Inc.