Enantioselective synthesis of 2‐ and 3‐substituted 2,3‐dihydro[1,4]dioxino[2,3‐ b ]pyridine derivatives and enantiomeric purity control by capillary electrophoresis | Zendy

Lazar S. | Zendy; Soukri M. | Zendy; El Haddad M. | Zendy; Akssira M. | Zendy; Leger J.M. | Zendy; Jarry C. | Zendy; Morin Ph. | Zendy; Guillaumet G. | Zendy

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Enantioselective synthesis of 2‐ and 3‐substituted 2,3‐dihydro[1,4]dioxino[2,3‐ b ]pyridine derivatives and enantiomeric purity control by capillary electrophoresis

Author(s) -

Lazar S.,

Soukri M.,

El Haddad M.,

Akssira M.,

Leger J.M.,

Jarry C.,

Morin Ph.,

Guillaumet G.

Publication year - 2004

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20090

Subject(s) - chemistry , capillary electrophoresis , enantioselective synthesis , enantiomer , pyridine , formic acid , chromatography , cyclodextrin , enantiomeric excess , organic chemistry , catalysis

A rapid and simple procedure for enantioselective preparation of 2‐ and 3‐substituted 2,3‐dihydro[1,4]dioxino[2,3‐ b ]pyridine derivatives ( A and B , respectively) is described. The enantiomeric purity of each isomer was determined by capillary electrophoresis using a dual‐cyclodextrin system ( S ‐β‐CD/β‐CD) dissolved in formic acid–ammonia buffer (pH 4, ionic strength 50 mM). Chirality 17:30–36, 2005. © 2004 Wiley‐Liss, Inc.

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