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Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers
Author(s) -
Thunberg Linda,
Allenmark Stig,
Friberg Annika,
Ek Fredrik,
Frejd Torbjörn
Publication year - 2004
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20080
Subject(s) - chemistry , chirality (physics) , chiral stationary phase , series (stratigraphy) , polymer , stereochemistry , enantiomer , organic chemistry , chiral symmetry , paleontology , physics , quantum mechanics , nambu–jona lasinio model , biology , quark
Two pairs of chiral stationary phases (CSPs) with different C 2 ‐symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs. Chirality 16:614–624, 2004. © 2004 Wiley‐Liss, Inc.