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Synthesis, complete characterization, and enantioselective electrokinetic separation of functionalized ruthenium complex enantiomers
Author(s) -
Holder Elisabeth,
Trapp Oliver,
Trapp Gabriele,
Marin Veronica,
Hoogenboom Richard,
Schubert Ulrich S.
Publication year - 2004
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20042
Subject(s) - chemistry , ruthenium , enantiomer , enantioselective synthesis , chirality (physics) , tetrafluoroborate , bipyridine , combinatorial chemistry , chiral column chromatography , stereochemistry , organic chemistry , catalysis , crystal structure , ionic liquid , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Electrokinetic chromatography was employed to separate the enantiomers of two novel functionalized ruthenium(II) complexes with different polypyridyl coordination spheres. The use of anionic carboxymethyl‐β‐cyclodextrin as chiral mobile phase additive resulted in maximum efficiency and resolution for the enantiomer separation of both transition metal complexes. The syntheses of the [4‐(3‐hydroxypropyl)‐4′‐methyl‐2,2′‐bipyridine]‐ bis (2,2′‐bipyridine)rethenium(II)‐ bis (tetrafluoroborate) and [4‐(3‐hydroxypropyl)‐4′‐methyl‐2,2′‐bipyridine]‐ bis (4,4′‐dimethyl‐2,2′‐bypyridine)ruthenium(II)‐ bis (tetrafluoroborate) complexes and their complete characterization by means of two‐dimensional 1 H and 13 C{ 1 H} NMR techniques ( 1 H– 1 H COSY and 1 H– 13 C HMQC) as well as elemental analyses and MALDI‐TOFMS are described in detail. The functionalized complexes can be used as building blocks for further reactions with polymers, biopolymers, surfaces and nanoparticles. Chirality 16:363–368, 2004. © Wiley‐Liss, Inc.