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Programmed assembly of rigid‐rod β‐barrel pores: Thermal inversion of chirality
Author(s) -
Sakai Naomi,
Matile Stefan
Publication year - 2004
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20034
Subject(s) - chemistry , supramolecular chirality , chirality (physics) , circular dichroism , supramolecular chemistry , crystallography , cationic polymerization , tripeptide , self assembly , stereochemistry , polymer chemistry , crystal structure , organic chemistry , peptide , quantum mechanics , nambu–jona lasinio model , quark , biochemistry , chiral symmetry breaking , physics
The programmed assembly of p ‐octiphenyl rods carrying six complementary tripeptide strands was studied in the presence of bilayer membranes using circular dichroism (CD) spectroscopy. Thermal CD experiments demonstrated programmed assembly of anionic and cationic rods into supramolecules at low temperature that irreversibly transform into more stable supramolecules at intermediate and high temperature. Higher activation energies for programmed assembly with rods containing multiple guanidinium rather than ammonium cations was consistent with stabilization by guanidinium‐anion complexes. Qualitative thermal inversion of supramolecular chirality during programmed assembly was detected continuously. Inversion of supramolecular chirality occurred with decreasing solvent polarity as well. Chirality 16:S28–S35, 2004 . © 2004 Wiley‐Liss, Inc.