Preparative resolution of 1‐aminoindan‐1,5‐dicarboxylic acid (AIDA) by chiral ligand‐exchange chromatography | Zendy

Natalini Benedetto | Zendy; Marinozzi Maura | Zendy; Bade Katrin | Zendy; Sardella Roccaldo | Zendy; Thomsen Christian | Zendy; Pellicciari Roberto | Zendy

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Preparative resolution of 1‐aminoindan‐1,5‐dicarboxylic acid (AIDA) by chiral ligand‐exchange chromatography

Author(s) -

Natalini Benedetto,

Marinozzi Maura,

Bade Katrin,

Sardella Roccaldo,

Thomsen Christian,

Pellicciari Roberto

Publication year - 2004

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.20027

Subject(s) - chemistry , enantiomer , resolution (logic) , ligand (biochemistry) , dicarboxylic acid , chromatography , chiral derivatizing agent , high performance liquid chromatography , chiral column chromatography , stereochemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry , artificial intelligence , computer science

Chiral ligand‐exchange chromatography has been shown to be effective in the resolution and semipreparative separation of 1‐aminoindan‐1,5‐dicarboxylic acid (AIDA) enantiomers. In functional activity experiments, only (S)‐AIDA was a potent and mGluR1 subtype selective antagonist. Chirality 16:314–317, 2004 . © 2004 Wiley‐Liss, Inc.

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