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Preparative resolution of 1‐aminoindan‐1,5‐dicarboxylic acid (AIDA) by chiral ligand‐exchange chromatography
Author(s) -
Natalini Benedetto,
Marinozzi Maura,
Bade Katrin,
Sardella Roccaldo,
Thomsen Christian,
Pellicciari Roberto
Publication year - 2004
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.20027
Subject(s) - chemistry , enantiomer , resolution (logic) , ligand (biochemistry) , dicarboxylic acid , chromatography , chiral derivatizing agent , high performance liquid chromatography , chiral column chromatography , stereochemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry , artificial intelligence , computer science
Chiral ligand‐exchange chromatography has been shown to be effective in the resolution and semipreparative separation of 1‐aminoindan‐1,5‐dicarboxylic acid (AIDA) enantiomers. In functional activity experiments, only (S)‐AIDA was a potent and mGluR1 subtype selective antagonist. Chirality 16:314–317, 2004 . © 2004 Wiley‐Liss, Inc.