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Solvent‐free optical resolution of N‐methylamphetamine by distillation after partial diastereoisomeric salt formation
Author(s) -
Kozma Dávid,
Fogassy Elemér
Publication year - 2001
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.1056
Subject(s) - chemistry , resolution (logic) , distillation , salt (chemistry) , crystallization , chiral resolution , solvent , enantiomer , organic chemistry , chromatography , artificial intelligence , computer science
Solvent‐free optical resolution of N‐methylamphetamine was developed by distillation after partial diastereoisomeric salt formation. From the 18 chiral acids tested by this method, five provide by this method resolution: O,O′‐dibenzoyltartaric acid, O,O′‐di‐p‐toluoyltartaric acid, 6‐methoxy‐α‐methyl‐2‐naphthaleneacetic acid (Naproxen), the cis ‐permetrinic acid, and the 2‐phenoxypropionic acid. Among them the O,O′‐dibenzoyltartaric acid in water‐free form provided the more effective resolution. The efficiency of this resolution S = 0.74 is in the range of the industrial‐scale resolutions and not worse than the efficiency achieved by optical resolution via fractional crystallization. Chirality 13:428–430, 2001. © 2001 Wiley‐Liss, Inc.