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Determination of enantiomerization barriers by dynamic and stopped‐flow chromatographic methods
Author(s) -
Trapp Oliver,
Schoetz Gabriele,
Schurig Volker
Publication year - 2001
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.1052
Subject(s) - chemistry , chromatography , isomerization , high performance liquid chromatography , chirality (physics) , chromatographic separation , organic chemistry , catalysis , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
In recent years, dynamic chromatography and stopped‐flow chromatographic techniques have become versatile tools for the determination of enantiomerization and isomerization barriers. Increasing demands for the stereochemical safety of chiral drugs contributed to the rapid development of new techniques. New computer‐aided evaluation systems allow the on‐line determination of interconversion barriers from the experimental chromatograms. Both dynamic chromatography and stopped‐flow chromatography have been applied to the entire range of chromatographic methods (GC, SFC, HPLC, CE). Chirality 13:403–414, 2001. © 2001 Wiley‐Liss, Inc.