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NMR studies of chiral recognition by cyclodextrins
Author(s) -
Dodziuk Helena,
Koźmiński Wiktor,
Ejchart Andrzej
Publication year - 2003
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.10304
Subject(s) - chemistry , diastereomer , chirality (physics) , enantiomer , cyclodextrin , molecular recognition , computational chemistry , proton nmr , relaxation (psychology) , organic chemistry , stereochemistry , molecule , chiral symmetry breaking , psychology , social psychology , physics , quantum mechanics , nambu–jona lasinio model , quark
Chiral recognition by cyclodextrins is of considerable importance, especially for pharmaceutical industry, in view of the possible side effects of the second enantiometer of chiral drugs. In general, it manifests itself in all NMR parameters (chemical shifts, coupling constants, NOE and ROE effects, and relaxation rates) on one hand. On the other hand, it allows one to determine the thermodynamic parameters characterizing diastereomeric complexes formed by cyclodextrins with enantiomeric guests. After an introduction and a general discussion of NMR manifestations of chiral recognition by cyclodextrin, the existing literature data on this problem will be discussed herein. Chirality 16:90–105, 2004 . © 2004 Wiley‐Liss, Inc