Premium
Absolute configuration of the thyroid hormone analog KAT‐2003 as determined by the 1 H NMR anisotropy method with a novel chiral auxiliary, MαNP acid
Author(s) -
Nishimura Toshihiro,
Taji Hiromi,
Harada Nobuyuki
Publication year - 2003
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.10301
Subject(s) - chemistry , absolute configuration , anisotropy , triglyceride , stereochemistry , cholesterol , biochemistry , physics , quantum mechanics
The absolute configuration of the chiral thyroid hormone analog KAT‐2003 (+)‐ 2 , showing hypocholesterolemic activities, decreases of hepatic triglyceride contents with lowering cardiac side effects, and significant inhibitory effect for the second primary hepatocellular carcinoma, was determined as S by the 1 H NMR anisotropy method using a novel chiral auxiliary, 2‐methoxy‐2‐(1‐naphtyl)propionic acid (MαNP acid). Chirality 16:13–21, 2004 . © 2003 Wiley‐Liss, Inc.