Absolute configuration of the thyroid hormone analog KAT‐2003 as determined by the  1 H NMR anisotropy method with a novel chiral auxiliary, MαNP acid | Zendy

Nishimura Toshihiro | Zendy; Taji Hiromi | Zendy; Harada Nobuyuki | Zendy

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Absolute configuration of the thyroid hormone analog KAT‐2003 as determined by the 1 H NMR anisotropy method with a novel chiral auxiliary, MαNP acid

Author(s) -

Nishimura Toshihiro,

Taji Hiromi,

Harada Nobuyuki

Publication year - 2003

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.10301

Subject(s) - chemistry , absolute configuration , anisotropy , triglyceride , stereochemistry , cholesterol , biochemistry , physics , quantum mechanics

The absolute configuration of the chiral thyroid hormone analog KAT‐2003 (+)‐ 2 , showing hypocholesterolemic activities, decreases of hepatic triglyceride contents with lowering cardiac side effects, and significant inhibitory effect for the second primary hepatocellular carcinoma, was determined as S by the 1 H NMR anisotropy method using a novel chiral auxiliary, 2‐methoxy‐2‐(1‐naphtyl)propionic acid (MαNP acid). Chirality 16:13–21, 2004 . © 2003 Wiley‐Liss, Inc.

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